Characterization of a binding site of UCN-01, a novel anticancer drug on α₁-Acid glycoproteinKURATA, N; MATSUSHITA, S; NISHI, K et al.Biological & pharmaceutical bulletin. 2000, Vol 23, Num 7, pp 893-895, issn 0918-6158Article

Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01)YANG, Li-Ying; HONG JIANG; RANGEL, Kelly M et al.Oncology reports. 2003, Vol 10, Num 5, pp 1489-1495, issn 1021-335X, 7 p.Article

Induction by staurosporine of hepatocyte growth factor production in human skin fibroblasts independent of protein kinase inhibitionYAGI, Yasuyuki; SOTANI, Tomohiro; NAGAO, Toshinori et al.Biochemical pharmacology. 2003, Vol 66, Num 9, pp 1797-1808, issn 0006-2952, 12 p.Article

Tissue distribution and plasma pharmacokinetics of UCN-01 at steady-state and following bolus administration in rats: Influence of human α₁-acid glycoprotein bindingHEDAYA, Mohsen A; DAOUD, Sayed S.Anticancer research. 2001, Vol 21, Num 6A, pp 4005-4010, issn 0250-7005Article

Small-molecule cyclin-dependent kinase modulatorsSENDEROWICZ, Adrian M.Oncogene (Basingstoke). 2003, Vol 22, Num 42, pp 6609-6620, issn 0950-9232, 12 p.Article

Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase CTAKAHASHI, I; KOBAYASHI, E; NAKANO, H et al.The Journal of pharmacology and experimental therapeutics. 1990, Vol 255, Num 3, pp 1218-1221, issn 0022-3565, 4 p.Article

Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinomaRINI, Brian I; WEINBERG, Vivian; SHAW, Vanessa et al.Cancer. 2004, Vol 101, Num 1, pp 90-95, issn 0008-543X, 6 p.Article

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to α₁-Acid glycoprotein in humansFUSE, E; TANII, H; TAKAI, K et al.Cancer research (Baltimore). 1999, Vol 59, Num 5, pp 1054-1060, issn 0008-5472Article

Development of a highly sensitive high-performance liquid chromatographic method for measuring an anticancer drug, UCN-01, in human plasma or urineKURATA, N; KURAMITSU, T; TANII, H et al.Journal of chromatography. B, Biomedical sciences and applications. 1998, Vol 708, Num 1-2, pp 223-227, issn 1387-2273Article

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I: Screening, producing organism and fermentationTAKAHASHI, I; ASANO, K; KAWAMOTO, I et al.Journal of antibiotics (Tokyo. 1968). 1989, Vol 42, Num 4, pp 564-570, issn 0021-8820, 7 p.Article

Cyclin-dependent kinases as new targets for the prevention and treatment of cancerSENDEROWICZ, Adrian M.Hematology/oncology clinics of North America. 2002, Vol 16, Num 5, issn 0889-8588, viii, 1229-1253 [25 p.]Article

UCN-01, a selective inhibitor of protein kinase C from StreptomycesTAKAHASHI, I; KOBAYASHI, E; ASANO, K et al.Journal of antibiotics (Tokyo. 1968). 1987, Vol 40, Num 12, pp 1782-1784, issn 0021-8820Article

Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G₂ cell cycle checkpointsLEVESQUE, Aime A; KOHN, Ethan A; BRESNICK, Edward et al.Oncogene (Basingstoke). 2005, Vol 24, Num 23, pp 3786-3796, issn 0950-9232, 11 p.Article

Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinomaMACK, Philip C; GANDARA, David R; LAU, Alvin H et al.Cancer chemotherapy and pharmacology. 2003, Vol 51, Num 4, pp 337-348, issn 0344-5704, 12 p.Article

Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01YEOW, W.-S; ZIAUDDIN, M. F; MAXHIMER, J. B et al.British journal of cancer. 2006, Vol 94, Num 10, pp 1436-1445, issn 0007-0920, 10 p.Article

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human α₁-Acid glycoproteinFUSE, E; TANII, H; FIGG, W. D et al.Cancer research (Baltimore). 1998, Vol 58, Num 15, pp 3248-3253, issn 0008-5472Article

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trialSAMPATH, Deepa; CORTES, Jorge; ESTROV, Zeev et al.Blood. 2006, Vol 107, Num 6, pp 2517-2524, issn 0006-4971, 8 p.Article

7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cellsBUNCH, R. T; EASTMAN, A.Cell growth and differentiation. 1997, Vol 8, Num 7, pp 779-788, issn 1044-9523Article

Development of a simplified, sensitive high-performance liquid chromatographic method using fluorescence detection to determine the concentration of UCN-01 in human plasmaSMITH, Judith A; CORTES, Jorge; NEWMAN, Robert A et al.Journal of chromatography. B, Biomedical sciences and applications. 2001, Vol 760, Num 2, pp 247-253, issn 1387-2273Article

The effect of different dosing schedules of UCN-01 on its pharmacokinetics and cardiohaemodynamics in dogsKURATA, N; IMABEPPU, S; NITOH, M et al.Journal of pharmacy and pharmacology. 2000, Vol 52, Num 11, pp 1327-1335, issn 0022-3573Article

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin : UCN-01, a selective protein kinase C inhibitorPOLLACK, I. F; KAWECKI, S; LAZO, J. S et al.Journal of neurosurgery. 1996, Vol 84, Num 6, pp 1024-1032, issn 0022-3085Article

The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x_L proteinBHONDE, Mandar R; HANSKI, Marie-Luise; HANSKI, Christoph et al.Oncogene (Basingstoke). 2005, Vol 24, Num 1, pp 148-156, issn 0950-9232, 9 p.Article

Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignanciesSENDEROWICZ, A. M.Leukemia. 2001, Vol 15, Num 1, pp 1-9, issn 0887-6924Article

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemiaKITADA, S; ZAPATA, J. M; ANDREEFF, M et al.Blood. 2000, Vol 96, Num 2, pp 393-397, issn 0006-4971Article

Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashionBREDEL, M; POLLACK, I. F; FREUND, J. M et al.Journal of neuro-oncology. 1999, Vol 41, Num 1, pp 9-20, issn 0167-594XArticle